Histologic case series of human acellular dermal matrix in superior capsule reconstruction
نویسندگان
چکیده
BackgroundAcellular dermal matrix (ADM) allografts are commonly used in the surgical treatment of complex and irreparable rotator cuff tears. Multiple studies report that superior capsule reconstruction (SCR) using ADM has resulted short-term clinical success as assessed via radiographic patient-reported outcomes. However, limited information is available regarding biologic fate these grafts human subjects. This case series describes histologic results from 8 patients who had reoperations, during which previously implanted ADMs were removed. These explanted subjected to analysis with hypothesis they would have evidence recellularization, revascularization, active remodeling.MethodsEight patients, 38-82 years old, underwent reoperation 6-38 months after undergoing SCR. explants voluntarily shipped manufacturer for analysis. Each graft’s structure composition qualitatively evaluated by 1 or more following stains: hematoxylin eosin, safranin O, Russell-Movat pentachrome. Pan-muscle actin staining also level neovascularization, potential myoblast myocyte infiltration, muscle tissue development graft, was analyzed determine proportion graft been recellularized situ.ResultsGrafts showed varying levels gross microscopic incorporation host. An uneven, but high, overall degree remodeling observed. The correlated implant duration. consistent successful shoulder capsule.ConclusionsThe present suggests SCR undergo early 6 implantation, recellularization positively correlates duration implantation. represent a significant advancement our knowledge Acellular remodeling. Eight situ. Grafts capsule.
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ژورنال
عنوان ژورنال: Journal of Shoulder and Elbow Surgery
سال: 2021
ISSN: ['1058-2746', '1532-6500']
DOI: https://doi.org/10.1016/j.jse.2021.01.019